Precision Brain Medicine through Simulation
Digital Twin of the Brain:
A Simulation-Based Approach to Clinical and Research Applications
VB Tech develops clinically validated digital brain twin technology to simulate large-scale brain dynamics using individual patient data.
These personalized models support the exploration of brain function and the evaluation of potential diagnostic and therapeutic strategies before they are applied in clinical settings.
The Science Behind It: The Virtual Brain
At the core of VB Tech’s technology is The Virtual Brain (TVB), a computational platform resulting from over two decades of research led by Viktor Jirsa and collaborators.
TVB uses structural and functional neuroimaging data (e.g., MRI, DTI, EEG, MEG) to simulate the spatiotemporal dynamics of brain activity at the whole-brain level.
Unlike traditional imaging, which provides static anatomical information, TVB produces dynamic simulations that reflect the interplay between brain structure and function. These digital twins allow users to:
- Simulate brain activity under both healthy and pathological conditions
- Reveal hidden disease mechanisms not directly accessible through standard imaging
- Simulate responses to interventions such as resections or stimulation
- Analyze network behavior and functional connectivity over time
By transforming multimodal data into mathematical models, TVB provides a framework for data-driven investigation of brain function and dysfunction.
Application to epilepsy
In the context of drug-resistant epilepsy, TVB is integrated into VB Tech’s clinical module VEP (Virtual Epileptic Patient™). This module uses patient-specific imaging and SEEG recordings to simulate seizure dynamics and identify potential epileptogenic zones.
Clinicians can compare simulated and recorded activity patterns, test virtual resections, and assess different surgical strategies before intervention. This approach supports informed planning and complements existing clinical workflows, for improved patient outcomes.
Clinically Proven Impact
VB Tech’s technology is not theoretical — it is clinically validated. Our approach is being tested in EPINOV, the largest clinical trial in epilepsy surgery to date, involving 13 leading centers and 356 patients with drug-resistant epilepsy.
A preliminary retrospective study on 53 patients showed a 29% improvement in the identification of epileptogenic zones compared to standard methods.
The EPINOV trial has completed its clinical phase and is now in the data analysis stage, reinforcing the clinical relevance of our approach.
While many AI solutions remain limited to data aggregation or pattern recognition, VB Tech goes further, delivering a mechanistic, interpretable model of brain function.
In collaboration with leading neurologists and neurosurgeons from the Institut des Neurosciences des Systèmes (Aix-Marseille University), our solutions are built by scientists, trusted by clinicians.
Scalable Beyond Epilepsy
The digital twin framework developed by VB Tech is designed to be applied across multiple domains. In addition to epilepsy, research is ongoing in conditions such as Alzheimer’s disease, Parkinson’s disease, M/S and schizophrenia, in collaboration with academic and clinical partners.
VB Tech: revealing the invisible
At its core, VB Tech’s strength is to make the invisible visible. With our digital brain twins, clinicians can visualize what conventional tools can’t… simulate, explore, and refine therapeutic strategies safely and precisely.
With a U.S. FDA submission underway and growing interest from top-tier hospitals in Europe, North America, and Asia, VB Tech is not just building software, we are shaping the future standard of care in neurology.
In the global movement toward precision medicine, VB Tech is not just participating, we are redefining what is possible for the patient.